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Olema Pharmaceuticals Inc (OLMA)

Breast Cancer · registered primary completion 2026-10-31 · NCT06016738

Published 2026-09-02Market cap $899M10 sourced statements
OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer · PHASE3 · n=510 · active not recruiting

Balance sheet

fact

Management has concluded there is substantial doubt about the company's ability to continue as a going concern.

“ations. As a development stage company, we expect to incur significant and increasing losses until regulatory approval is granted for palazestrant or OP-3136. Regulatory approval is not guaranteed and may never be obtained. As a result, these conditions raise substantial doubt about our ability to continue as a going concern over the long term. We have never generated revenue from product sales and may never be profi…”

Runway

fact

Cash of $461M against operating outflow of $55M per quarter gives roughly 8.4 quarters of runway, clearing the registered primary completion 0.7 quarters out by 7.7 quarters.

Share count and dilution

fact

87,497,607 shares outstanding against 106,431,993 if every outstanding option, warrant and convertible were exercised. In that case 17.8% of a gain in enterprise value would accrue to those holders rather than to current shareholders.

fact

23,084,149 pre-funded warrant shares outstanding at a nominal exercise price — economically issued equity.

fact

Share count up 28% year over year to 87,497,607 as of 2026-08-06.

Market

fact

6 approved products already carry Breast Cancer on label, including Doxorubicin Hydrochloride, capecitabine, Docetaxel, Fulvestrant. Approval would enter an occupied market.

Trial registry

fact

Registered design for NCT06016738: randomized, open-label, 510 participants (estimated). Primary outcome: Dose-Selection Part: Incidence of adverse events. 3 further primary outcome(s) registered.

Regulatory

fact

Designations disclosed: Breakthrough Therapy, Fast Track, Orphan Drug, PRIME (EU). These accelerate review and, for Orphan, confer exclusivity if approved; none is evidence of efficacy.

Pipeline

fact

12 distinct molecules in 5 active company-sponsored trials; Palazestrant accounts for 5 of them at Phase 1/Phase 3.

Ownership and proceedings

fact

Directors and executive officers as a group hold 12.56%.

This sheet is dated and will not be edited. When the registered primary completion passes, its outcome is recorded on the scoreboard and a new dated sheet is published if the filings change materially.